What is the 2',3'-O-ISOPROPYLIDENEURIDINE?

2',3'-O-ISOPROPYLIDENEURIDINE is , while it's Molecular Formula is C12H16N2O6. 2',3'-O-Isopropylideneuridine can be used as a useful precursor for the preparation of nucleic acids.

What is the CAS number for 2',3'-O-ISOPROPYLIDENEURIDINE?

The CAS number of 2',3'-O-ISOPROPYLIDENEURIDINE is 362-43-6.

What is 2',3'-O-ISOPROPYLIDENEURIDINE (362-43-6) used for?

2',3'-Isopropylideneuridine has been shown to inhibit binding of pestivirus inhibitors by monoclonal antibodies. 2',3'-Isopropylideneuridine was also found to inhibit the replication of human immunodeficiency virus (HIV) in tissue culture by binding to the viral RNA polymerase and inhibiting its activity, preventing viral replication.

What is the 2',3'-O-ISOPROPYLIDENEURIDINE?

2',3'-O-ISOPROPYLIDENEURIDINE is , while it's Molecular Formula is C12H16N2O6. 2',3'-O-Isopropylideneuridine can be used as a useful precursor for the preparation of nucleic acids.

What is the CAS number for 2',3'-O-ISOPROPYLIDENEURIDINE?

The CAS number of 2',3'-O-ISOPROPYLIDENEURIDINE is 362-43-6.

What is 2',3'-O-ISOPROPYLIDENEURIDINE (362-43-6) used for?

2',3'-Isopropylideneuridine has been shown to inhibit binding of pestivirus inhibitors by monoclonal antibodies. 2',3'-Isopropylideneuridine was also found to inhibit the replication of human immunodeficiency virus (HIV) in tissue culture by binding to the viral RNA polymerase and inhibiting its activity, preventing viral replication.

2',3'-O-Isopropylideneuridine

Basic information

Product Name:2',3'-O-Isopropylideneuridine
CasNo.:362-43-6
MF:C₁₂H₁₆N₂O₆
MW:284.269

Physical and Chemical Properties

Boiling Point:163-166 °C
Packing:25kg/drum or as required by customer
Throughput:

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Product Details

CasNo： 362-43-6

MF： C₁₂H₁₆N₂O₆

Packing： 25kg/drum or as required by customer

Factory Supply industrial standard 2',3'-O-Isopropylideneuridine 362-43-6 In Stock

Synonyms: Isopropylideneuridine；2',3'-O-Isopropylidene-D-uridine；Uridine,2',3'-O-(1-methylethylidene)-；Uridine,2',3'-O-isopropylidene；Uridine 2',3'-acetonide

Molecular Formula: C₁₂H₁₆N₂O₆

Molecular Weight: 284.27

CAS Number：362-43-6

Molecular Structure:

Item	Specification
Appearance	White to off-white crystalline powder
Assay (HPLC),%	≥98.0
Melting Point, ℃	163.0~168.0
Loss on drying,%	≤1.0
Residue on ignition,%	≤0.10

Characteristics:It is white to off-white crystalline powder. It is easily soluble in water and slightly soluble in methanol.

2’3’-O-Isopropylideneuridine(Cas 362-43-6) Usage

Monupivir (Molnupiravir) is a broad-spectrum anti-RNA virus drug, which has obvious effect on novel coronavirus (COVID-19)，significant inhibitory effect on the proliferation of SARS-CoV-2 virus. It is the first oral anti-novel coronavirus drug in the world, which can reduce the risk of hospitalization or death by 50% of COVID-19 patients. 2 ′, 3 ′ -O-isoisopropyl uridine is an important intermediate in Molnupiravir synthesis.

Storage: Store in a tightly closed container. Maintain in a cool and dry area.

Package: 25kg/drum or as required by customer.

Expiration Date: 2 years

362-43-6 Relevant articles

5',6'-Nucleoside phosphonate analogues architecture: Synthesis and comparative evaluation towards metabolic enzymes

Gallier, Franck,Alexandre, Julie A. C.,ElAmri, Chahrazade,Deville-Bonne, Dominique,Peyrottes, Suzanne,Perigaud, Christian

, p. 1094 - 1106 (2011)

Nucleoside phosphonates have been design...

Synthesis and utility of novel C-meso-glycosylated metalloporphyrins

Cornia, Mara,Menozzi, Monica,Ragg, Enzio,Mazzini, Stefania,Scarafoni, Alessio,Zanardi, Franca,Casiraghi, Giovanni

, p. 3977 - 3983 (2000)

Novel hybrid porphyrins bearing two and ...

Flexible nucleobase receptor - Effect of self-preorganization of artificial receptor

Kuroda, Yasuhisa,Lintuluoto, Juha M.,Ogoshi, Hisanobu

, p. 3729 - 3732 (1994)

A new type flexible receptor which has t...

Novel bisubstrate uridine-peptide analogues bearing a pyrophosphate bioisostere as inhibitors of human O-GlcNAc transferase

Ryan, Philip,Shi, Yun,von Itzstein, Mark,Rudrawar, Santosh

, (2021)

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Rapid Synthesis of a Natural Product-Inspired Uridine Containing Library

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, p. 600 - 607 (2020)

The preparation of natural product-inspi...

A Simple Conversion of 5-Cyanouridine into Uridine

Mincher, David J.,Shaw, Gordon

, p. 1488 - 1489 (1986)

2',3'-O-Isopropylideneuridine (4) was pr...

Effect of uridine protecting groups on the diastereoselectivity of uridine-derived aldehyde 5’-alkynylation

Othman, Raja Ben,Fer, Micka?l J.,Le Corre, Laurent,Calvet-Vitale, Sandrine,Gravier-Pelletier, Christine

, p. 1533 - 1541 (2017)

The 5′-alkynylation of uridine-derived a...

Synthesis and antibacterial activity of 5′-tetrachlorophthalimido and 5′-azido 5′-deoxyribonucleosides

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, p. 181 - 197 (2017)

Reported is an efficient synthesis of ad...

Evaluation of BBB permeable nucleolipid (NLDPU): A di-C15-ketalised palmitone appended uridine as neuro-tracer for SPECT

Swastika,Chaturvedi, Shubhra,Kaul, Ankur,Hazari, Puja Panwar,Jha, Preeti,Pal, Sunil,Lal, Sangeeta,Singh,Barthélémy, Philippe,Mishra, Anil K.

, p. 269 - 282 (2019)

Despite being in routine for onco-diagno...

Deploying Fluorescent Nucleoside Analogues for High-Throughput Inhibitor Screening

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, p. 108 - 112 (2020)

High-throughput small-molecule screening...

Photophysical properties of zinc phthalocyanine-uridine single walled carbon nanotube - Conjugates

Ogbodu, Racheal O.,Amuhaya, Edith K.,Mashazi, Philani,Nyokong, Tebello

, p. 231 - 239 (2015)

The photophysical properties of the conj...

-

Srivastava,Rousseau

, p. 455 (1973)

Efficient synthesis and antifungal investigation of nucleosides’ quaternary ammonium salt derivatives

Dmochowska, Barbara,Pellowska-Januszek, Lucyna,Samaszko-Fiertek, Justyna,Slusarz, Rafal,Wakiec, Roland,Madaj, Janusz

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A Modular Approach to Phosphoglycosyltransferase Inhibitors Inspired by Nucleoside Antibiotics

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, p. 3856 - 3864 (2016)

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Selectivity in C-alkylation of dianions of protected 6-methyluridine

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, p. 1228 - 1233 (2011)

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, p. 5004 - 5012 (2015)

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Herein is described the development of a...

362-43-6 Process route

: 77-76-9
2,2-dimethoxy-propane

: 58-96-8
uridine

: 362-43-6
2',3'-O-isopropylideneuridine

Conditions

Conditions	Yield
With toluene-4-sulfonic acid; In acetone; for 1h; Reflux;	100%
With toluene-4-sulfonic acid; In acetone; for 4h; Reflux;	100%
With toluene-4-sulfonic acid; In acetone; for 1h; Reflux;	99%
With toluene-4-sulfonic acid; In acetone; at 60 ℃; for 24h; Inert atmosphere;	96%
With toluene-4-sulfonic acid; In acetone; at 60 ℃; for 24h;	96%
With toluene-4-sulfonic acid; In acetonitrile; for 3h; Inert atmosphere; Reflux;	95%
With toluene-4-sulfonic acid; In acetonitrile; for 3h; Reflux;	94%
With toluene-4-sulfonic acid; In acetonitrile; for 3h; Reflux;	94%
With toluene-4-sulfonic acid; In acetone; at 20 ℃; for 2h;	93%
With sulfuric acid; In acetone; at 0 - 55 ℃; for 8.5h; Time; Industrial scale;	91%
With toluene-4-sulfonic acid; In N,N-dimethyl-formamide;	90%
With toluene-4-sulfonic acid; In acetone; at 20 ℃; for 1.5h; Inert atmosphere;	90%
With toluene-4-sulfonic acid; In acetone; at 20 ℃; Inert atmosphere;	88%
With toluene-4-sulfonic acid; at 20 ℃; for 3h;	85%
With toluene-4-sulfonic acid; In water; acetone; at 60 ℃; for 2h; Inert atmosphere;	81%
With toluene-4-sulfonic acid; In acetone; at 60 ℃; for 2h; Inert atmosphere;	81%
With toluene-4-sulfonic acid; In acetone; at 20 ℃;	80%
	79%
With toluene-4-sulfonic acid; In acetone; for 24h; Reflux; Inert atmosphere;	79%
With toluene-4-sulfonic acid; In acetone;	73%
With toluene-4-sulfonic acid; In acetone; at 0 ℃; for 1h; Reflux; Inert atmosphere;	65%
With toluene-4-sulfonic acid; In N,N-dimethyl-formamide; at 20 ℃; for 18h;	61%
With DOWEX (50WX₈) ion exchange resin (H⁺); In acetone;	58%
With toluene-4-sulfonic acid; In N,N-dimethyl-formamide; at 40 ℃; for 3h; Molecular sieve;	56%
With toluene-4-sulfonic acid; In N,N-dimethyl-formamide; at 40 ℃; for 1.5h; Inert atmosphere; Molecular sieve;	24.8%
With toluene-4-sulfonic acid;
With toluene-4-sulfonic acid; In tetrahydrofuran;
2,2-dimethoxy-propane; uridine; With toluene-4-sulfonic acid; In water; N,N-dimethyl-formamide; at 45 ℃; for 2h; Molecular sieve; With Amberlyst A-21 resin; In water; N,N-dimethyl-formamide; at 20 ℃; for 0.333333h;
With sulfuric acid; In acetone; Inert atmosphere;	45 g
With toluene-4-sulfonic acid; In N,N-dimethyl-formamide;
2,2-dimethoxy-propane; uridine; In acetone; for 0.166667h; With sulfuric acid; In acetone; at 20 ℃; for 0.5h;

: 191479-26-2
3-((benzyloxy)methyl)-1-((3aR,4R,6R,6aR)-6-(hydroxymethyl)-2,2-dimethyltetrahydrofuro[3,4-d][1,3]dioxol-4-yl)pyrimidine-2,4(1H,3H)-dione

: 362-43-6
2',3'-O-isopropylideneuridine

Conditions

Conditions	Yield
With formic acid; palladium on activated charcoal; hydrogen; In water; isopropyl alcohol; for 6h; under 760.051 Torr;	99%